› 6ty4

Electron Microscopy
5.96Å resolution

FAK structure with AMP-PNP from single particle analysis of 2D crystals

Released:
DOI: 10.2210/pdb6ty4/pdb
PDB entry 6ty4 coloured by chain, front view.
PDB entry 6ty4 coloured by chain, side view.
PDB entry 6ty4 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structural basis of Focal Adhesion Kinase activation on lipid membranes.
Acebrón I, Righetto RD, Schoenherr C, de Buhr S, Redondo P, Culley J, Rodríguez CF, Daday C, Biyani N, Llorca O, Byron A, Chami M, Gräter F, Boskovic J, Frame MC, Stahlberg H, Lietha D
EMBO J 39 e104743 (2020)
PMID: 32779739
Related structures: EMD-10616

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169486 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 658 amino acids
Theoretical weight: 75.48 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q00944 (Residues: 30-686; Coverage: 62%)
Gene names: FAK, FAK1, PTK2
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand ANP 2 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.96Å
Relevant EMDB volumes: EMD-10616
Expression system: Homo sapiens

Quick links

Citations

13 review citations

Targeting FAK in anticancer combination therapies.
Dawson et al. (2021)
12 more