› 6tzc

X-ray diffraction
2.41Å resolution

Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin

Released:
DOI: 10.2210/pdb6tzc/pdb
Model geometry
Data not analysed
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PDB entry 6tzc coloured by chain, front view.
PDB entry 6tzc coloured by chain, side view.
PDB entry 6tzc coloured by chain, top view.
Source organisms:
Primary publication:
Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin.
Banjara S, Shimmon GL, Dixon LK, Netherton CL, Hinds MG, Kvansakul M
OpenAccess logo Viruses 11 (2019)
PMID: 31461953

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-142621 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Maltose/maltodextrin-binding periplasmic protein Chain: A
Molecule details ›
Chain: A
Length: 371 amino acids
Theoretical weight: 40.68 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
Gene names: JW3994, b4034, malE
Sequence domains: Bacterial extracellular solute-binding protein
Apoptosis regulator Bcl-2 homolog Chain: B
Molecule details ›
Chain: B
Length: 154 amino acids
Theoretical weight: 18.13 KDa
Source organism: African swine fever virus BA71V
Expression system: Escherichia coli
UniProt:
  • Canonical: P42485 (Residues: 1-148; Coverage: 83%)
Gene names: A179L, Ba71V-041
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Beclin-1 Chain: C

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 54.565Å b: 44.347Å c: 129.022Å
α: 90° β: 94.532° γ: 90°
R-values:
R R work R free
0.216 0.214 0.253
Expression systems:
  • Escherichia coli
  • Not provided

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Citations

8 review citations

Current State of Global African Swine Fever Vaccine Development under the Prevalence and Transmission of ASF in China.
Wu et al. (2020)
7 more

2 mentions without citation

Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin.
Banjara et al. (2019)
1 more

PDB-REDO

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