› 6u0k

X-ray diffraction
1.74Å resolution

TTBK2 kinase domain in complex with Compound 1

Released:
DOI: 10.2210/pdb6u0k/pdb
PDB entry 6u0k coloured by chain, front view.
PDB entry 6u0k coloured by chain, side view.
PDB entry 6u0k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor
Marcotte DJ, Spilker KA, Wen D, Hesson T, Patterson TA, Kumar R, Chodaparambil JV
Acta Crystallogr F Struct Biol Commun 76 103-108 (2020)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179775 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tau-tubulin kinase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 300 amino acids
Theoretical weight: 34.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6IQ55 (Residues: 1-299; Coverage: 24%)
Gene names: KIAA0847, TTBK2
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand PO4 8 x PO4
Ligand DTQ 2 x DTQ
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 56.23Å b: 114.68Å c: 118.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.233
Expression system: Escherichia coli

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