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AAV8 human HEK293-produced, empty capsid

Electron Microscopy
3.3Å resolution
PDB entry 6u20 coloured by chain, front view.
PDB entry 6u20 coloured by chain, side view.
PDB entry 6u20 coloured by chain, top view.
Source organism: Adeno-associated virus - 8
Assembly composition:
homo 60-mer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Capsid protein
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Multimeric state: homo 60-mer
Accessible surface area: 913566.78 Å2
Buried surface area: 974033.02 Å2
Dissociation area: 186,744.97 Å2
Dissociation energy (ΔGdiss): 2,337.6 kcal/mol
Dissociation entropy (TΔSdiss): 370.92 kcal/mol
Symmetry number: 60
PDBe Complex ID: PDB-CPX-185014

Macromolecules

Capsid protein
Chain: A
Length: 519 amino acids
Theoretical weight: 58.53 KDa
Source organism: Adeno-associated virus - 8
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8JQF8 (Residues: 220-738; Coverage: 70%)
Pfam: Parvovirus coat protein VP2
InterPro:
Capsid protein in PDB entry 6u20, assembly 1, front view.
Capsid protein in PDB entry 6u20, assembly 1, side view.
Capsid protein in PDB entry 6u20, assembly 1, top view.
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