› 6u3n

X-ray diffraction
2.8Å resolution

LS2.8/3.15 - DQ2-P.fluor-alpha1a complex

Released:
DOI: 10.2210/pdb6u3n/pdb
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PDB entry 6u3n coloured by chain, front view.
PDB entry 6u3n coloured by chain, side view.
PDB entry 6u3n coloured by chain, top view.
Source organisms:
Primary publication:
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.
Petersen J, Ciacchi L, Tran MT, Loh KL, Kooy-Winkelaar Y, Croft NP, Hardy MY, Chen Z, McCluskey J, Anderson RP, Purcell AW, Tye-Din JA, Koning F, Reid HH, Rossjohn J
Nat Struct Mol Biol 27 49-61 (2020)
PMID: 31873306

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-208064 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
T-CELL RECEPTOR, LS2.8/3.15 alpha Chain: D
Molecule details ›
Chain: D
Length: 206 amino acids
Theoretical weight: 22.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
T-CELL RECEPTOR, LS2.8/3.15 beta Chain: E
Molecule details ›
Chain: E
Length: 244 amino acids
Theoretical weight: 27.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
HLA class II histocompatibility antigen, DQ alpha 1 chain Chain: A
Ig-like domain-containing protein Chain: B
Peptide Chain: C

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: C2221
Unit cell:
a: 59.98Å b: 239.47Å c: 147.46Å
α: 90° β: 90° γ: 90°
Expression systems:
  • Escherichia coli
  • Trichoplusia ni

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Citations

25 review citations

The microbiome and human cancer.
Sepich-Poore et al. (2021)
24 more

3 mentions without citation

The Many Faces of CD4+ T Cells: Immunological and Structural Characteristics.
Chatzileontiadou et al. (2020)
2 more

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