› 6u3s

Solution NMR

Solution NMR structure of the DNAJB6b deltaST variant (Aligned on the CTD domain)

Released:
DOI: 10.2210/pdb6u3s/pdb
PDB entry 6u3s coloured by chain, ensemble of 10 models, front view.
PDB entry 6u3s coloured by chain, ensemble of 10 models, side view.
PDB entry 6u3s coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Unraveling the structure and dynamics of the human DNAJB6b chaperone by NMR reveals insights into Hsp40-mediated proteostasis.
Karamanos TK, Tugarinov V, Clore GM
Proc Natl Acad Sci U S A 116 21529-21538 (2019)
PMID: 31591220

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-521940 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DnaJ homolog subfamily B member 6 Chain: A
Molecule details ›
Chain: A
Length: 190 amino acids
Theoretical weight: 21.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75190 (Residues: 1-127, 184-231; Coverage: 54%)
  • Best match: O75190-2 (Residues: 1-127, 184-241)
Gene names: DNAJB6, HSJ2, MRJ, MSJ1
Sequence domains: DnaJ domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 38%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Neuromuscular Diseases Due to Chaperone Mutations: A Review and Some New Results.
Sarparanta et al. (2020)
7 more

3 mentions without citation

J-domain protein chaperone circuits in proteostasis and disease.
Zhang et al. (2023)
2 more