› 6u65

X-ray diffraction
2.09Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170534 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Induced myeloid leukemia cell differentiation protein Mcl-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 156 amino acids
Theoretical weight: 17.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07820 (Residues: 171-323; Coverage: 44%)
Gene names: BCL2L3, MCL1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family

Ligands and Environments

4 bound ligands:
Ligand Q0A 4 x Q0A
Ligand EDO 7 x EDO
Ligand ACT 5 x ACT
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 69.712Å b: 85.223Å c: 109.753Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.222
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Targeting MCL-1 in cancer: current status and perspectives.
Wang et al. (2021)
2 more

1 mention without citation

Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
Kump et al. (2020)