› 6u6n

X-ray diffraction
2.15Å resolution

Structure of the trimeric globular domain of Adiponectin mutant - D187A Q188A

Released:
DOI: 10.2210/pdb6u6n/pdb
PDB entry 6u6n coloured by chain, front view.
PDB entry 6u6n coloured by chain, side view.
PDB entry 6u6n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mapping and engineering the interaction between adiponectin and T-cadherin.
Pascolutti R, Erlandson SC, Burri DJ, Zheng S, Kruse AC
J Biol Chem 295 2749-2759 (2020)
PMID: 31915248

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172431 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adiponectin Chain: C
Molecule details ›
Chain: C
Length: 143 amino acids
Theoretical weight: 16.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15848 (Residues: 108-244; Coverage: 61%)
Gene names: ACDC, ACRP30, ADIPOQ, APM1, GBP28
Sequence domains: C1q domain

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: R3
Unit cell:
a: 75.704Å b: 75.704Å c: 48.865Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.21 0.256
Expression system: Escherichia coli

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Citations

6 review citations

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis.
Schüler-Toprak et al. (2022)
5 more

1 mention without citation

Mapping and engineering the interaction between adiponectin and T-cadherin.
Pascolutti et al. (2020)