› 6u8l

X-ray diffraction
1.57Å resolution

Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction

Released:
DOI: 10.2210/pdb6u8l/pdb
PDB entry 6u8l coloured by chain, front view.
PDB entry 6u8l coloured by chain, side view.
PDB entry 6u8l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
Macdonald JD, Chacón Simon S, Han C, Wang F, Shaw JG, Howes JE, Sai J, Yuh JP, Camper D, Alicie BM, Alvarado J, Nikhar S, Payne W, Aho ER, Bauer JA, Zhao B, Phan J, Thomas LR, Rossanese OW, Tansey WP, Waterson AG, Stauffer SR, Fesik SW
J Med Chem 62 11232-11259 (2019)
PMID: 31724864

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-548805 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 304 amino acids
Theoretical weight: 33.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P61964 (Residues: 31-334; Coverage: 91%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat

Ligands and Environments

2 bound ligands:
Ligand Q1P 2 x Q1P
Ligand Q1S 2 x Q1S
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: C2
Unit cell:
a: 134.65Å b: 47.082Å c: 113.052Å
α: 90° β: 117.91° γ: 90°
R-values:
R R work R free
0.153 0.151 0.176
Expression system: Escherichia coli K-12

Quick links

Citations

6 review citations

MYC protein interactors in gene transcription and cancer.
Lourenco et al. (2021)
5 more

1 mention without citation

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
Macdonald et al. (2019)