› 6ubi

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137925 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin gamma-1 heavy chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 229 amino acids
Theoretical weight: 24.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DOX5 (Residues: 4-100, 101-226; Coverage: 50%)
Sequence domains:
Ig-like domain-containing protein Chains: B, E
Molecule details ›
Chains: B, E
Length: 212 amino acids
Theoretical weight: 23.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6GMX0 (Residues: 23-234; Coverage: 99%)
Sequence domains:
Transmembrane protein gp41 Chains: C, F
Molecule details ›
Chains: C, F
Length: 8 amino acids
Theoretical weight: 733 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 512-519; Coverage: 1%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 80.933Å b: 44.278Å c: 125.375Å
α: 90° β: 96.2° γ: 90°
R-values:
R R work R free
0.239 0.237 0.288
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

3 review citations

Neutralizing Antibodies Targeting HIV-1 gp41.
Caillat et al. (2020)
2 more

1 mention without citation

VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.
Shen et al. (2020)