› 6ue7

Electron Microscopy
2.9Å resolution

Structure of dimeric sIgA complex

Released:
DOI: 10.2210/pdb6ue7/pdb
PDB entry 6ue7 coloured by chain, front view.
PDB entry 6ue7 coloured by chain, side view.
PDB entry 6ue7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the secretory immunoglobulin A core.
Kumar N, Arthur CP, Ciferri C, Matsumoto ML
Science 367 1008-1014 (2020)
PMID: 32029686
Related structures: EMD-20749

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-134433 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Immunoglobulin heavy constant alpha 1 Chains: A, B, F, G
Molecule details ›
Chains: A, B, F, G
Length: 245 amino acids
Theoretical weight: 26.67 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Polymeric immunoglobulin receptor Chain: C
Molecule details ›
Chain: C
Length: 591 amino acids
Theoretical weight: 65.15 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Immunoglobulin J chain Chain: D
Molecule details ›
Chain: D
Length: 137 amino acids
Theoretical weight: 15.61 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 7 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-20749
Expression system: Cricetulus griseus

Quick links

Citations

13 review citations

Structure, Function, and Therapeutic Use of IgM Antibodies.
Keyt et al. (2020)
12 more

11 mentions without citation

3D Structures of IgA, IgM, and Components.
Pan et al. (2021)
10 more