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Structure of pentameric sIgA complex

Electron Microscopy
3Å resolution
PDB entry 6uea coloured by chain, front view.
PDB entry 6uea coloured by chain, side view.
PDB entry 6uea coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dodecamer
Accessible surface area: 151383.99 Å2
Buried surface area: 40638.74 Å2
Dissociation area: 1,611.14 Å2
Dissociation energy (ΔGdiss): 1.85 kcal/mol
Dissociation entropy (TΔSdiss): 16.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134434

Macromolecules

Immunoglobulin heavy constant alpha 2
Chains: A, B, E, F, G, H, I, J, K, L
Length: 245 amino acids
Theoretical weight: 26.68 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01877 (Residues: 110-321; Coverage: 54%)
  • Best match: P01877-1 (Residues: 110-340)
Gene name: IGHA2
Pfam:
InterPro:
Immunoglobulin heavy constant alpha 2 in PDB entry 6uea, assembly 1, front view.
Immunoglobulin heavy constant alpha 2 in PDB entry 6uea, assembly 1, side view.
Immunoglobulin heavy constant alpha 2 in PDB entry 6uea, assembly 1, top view.
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Secretory component
Chain: C
Length: 591 amino acids
Theoretical weight: 65.15 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01833 (Residues: 19-603; Coverage: 78%)
Gene name: PIGR
Pfam: Immunoglobulin V-set domain
InterPro:
Secretory component in PDB entry 6uea, assembly 1, front view.
Secretory component in PDB entry 6uea, assembly 1, side view.
Secretory component in PDB entry 6uea, assembly 1, top view.
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Immunoglobulin J chain
Chain: D
Length: 137 amino acids
Theoretical weight: 15.61 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01591 (Residues: 23-159; Coverage: 100%)
Gene names: IGCJ, IGJ, JCHAIN
Pfam: Immunoglobulin J chain
InterPro: Immunoglobulin J chain
Immunoglobulin J chain in PDB entry 6uea, assembly 1, front view.
Immunoglobulin J chain in PDB entry 6uea, assembly 1, side view.
Immunoglobulin J chain in PDB entry 6uea, assembly 1, top view.
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