› 6uio

X-ray diffraction
1.83Å resolution

Crystal structure of mouse CRES (Cystatin-Related Epididymal Spermatogenic)

Released:
DOI: 10.2210/pdb6uio/pdb
Model geometry
Fit model/data
PDB entry 6uio coloured by chain, front view.
PDB entry 6uio coloured by chain, side view.
PDB entry 6uio coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Maturation of the functional mouse CRES amyloid from globular form.
Hewetson A, Khan NH, Dominguez MJ, Do HQ, Kusko RE, Borcik CG, Rigden DJ, Keegan RM, Sutton RB, Latham MP, Wylie BJ, Cornwall GA
Proc Natl Acad Sci U S A 117 16363-16372 (2020)
PMID: 32601205

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152439 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystatin-8 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 112 amino acids
Theoretical weight: 13 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P32766 (Residues: 31-142; Coverage: 91%)
Gene names: Cres, Cst8
Sequence domains: Cystatin domain

Ligands and Environments

6 bound ligands:
Ligand IOD 22 x IOD
Ligand SO4 18 x SO4
Ligand I2I 2 x I2I
Ligand CL 8 x CL
Ligand MES 2 x MES
Ligand NA 6 x NA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 51.048Å b: 85.924Å c: 111.677Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.224 0.262
Expression system: Escherichia coli

Quick links

Citations

4 citation in other articles

Host defense functions of the epididymal amyloid matrix.
Myers et al. (2022)
3 more

3 mentions without citation

Artificial Iron Proteins: Modeling the Active Sites in Non-Heme Dioxygenases.
Miller et al. (2020)
2 more