› 6ul7

X-ray diffraction
2.3Å resolution

Structure of human ketohexokinase-C in complex with fructose, NO3, and osthole

Released:
DOI: 10.2210/pdb6ul7/pdb
PDB entry 6ul7 coloured by chain, front view.
PDB entry 6ul7 coloured by chain, side view.
PDB entry 6ul7 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gasper WC, Gardner S, Allen KN, Tolan DR

Function and Biology Details

Reaction catalysed: 
ATP + D-fructose = ADP + D-fructose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156119 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ketohexokinase Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 34.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P50053 (Residues: 1-298; Coverage: 100%)
Gene name: KHK
Sequence domains: pfkB family carbohydrate kinase

Ligands and Environments

3 bound ligands:
Ligand FRU 1 x FRU
Ligand A0O 1 x A0O
Ligand NO3 1 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P43212
Unit cell:
a: 106.87Å b: 106.87Å c: 79.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.229 0.278
Expression system: Escherichia coli BL21(DE3)

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