6umg

X-ray diffraction
2.7Å resolution

Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor

Released:
Model geometry
Data not analysed
Fit model/data
Data not analysed

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-279369 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
erenumab Fab heavy chain, IgG1 Chains: H, h
Molecule details ›
Chains: H, h
Length: 237 amino acids
Theoretical weight: 25.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
erenumab Fab light chain, IgG1 Chains: L, l
Molecule details ›
Chains: L, l
Length: 216 amino acids
Theoretical weight: 22.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Calcitonin gene-related peptide type 1 receptor Chains: C, c
Receptor activity-modifying protein 1 Chains: R, r

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 70.464Å b: 112.52Å c: 77.254Å
α: 90° β: 91.84° γ: 90°
R-values:
R R work R free
0.247 0.245 0.282
Expression systems:
  • Homo sapiens
  • Escherichia coli BL21(DE3)