› 6uox

Electron Microscopy
4.13Å resolution

Structure of itraconazole-bound NPC1

Released:
DOI: 10.2210/pdb6uox/pdb
PDB entry 6uox coloured by chain, front view.
PDB entry 6uox coloured by chain, side view.
PDB entry 6uox coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for itraconazole-mediated NPC1 inhibition.
Long T, Qi X, Hassan A, Liang Q, De Brabander JK, Li X
OpenAccess logo Nat Commun 11 152 (2020)
PMID: 31919352
Related structures: EMD-20834

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127297 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
NPC intracellular cholesterol transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 1286 amino acids
Theoretical weight: 143.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15118 (Residues: 1-1278; Coverage: 100%)
Gene name: NPC1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 8 x NAG
Ligand QDG 1 x QDG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.13Å
Relevant EMDB volumes: EMD-20834
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling.
Qi et al. (2020)
6 more

7 mentions without citation

Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.
Alav et al. (2021)
6 more