› 6us2

X-ray diffraction
1.8Å resolution

Function and Biology Details

Reaction catalysed: 
2-hydroxy-dATP + H(2)O = 2-hydroxy-dAMP + diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxidized purine nucleoside triphosphate hydrolase Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 18.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P36639 (Residues: 1-156; Coverage: 100%)
Gene names: MTH1, NUDT1
Sequence domains: NUDIX domain

Ligands and Environments

1 bound ligand:
Ligand S3O 1 x S3O
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Unit cell:
a: 36.315Å b: 59.953Å c: 66.672Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.176 0.234
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Role of the NUDT Enzymes in Breast Cancer.
Wright et al. (2021)
3 other articles

1 mention without citation

Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.
Farand et al. (2020)