› 6uux

X-ray diffraction
1.5Å resolution

Schistosoma mansoni (Blood Fluke) Sulfotransferase/Hycanthone Complex

Released:
DOI: 10.2210/pdb6uux/pdb
PDB entry 6uux coloured by chain, front view.
PDB entry 6uux coloured by chain, side view.
PDB entry 6uux coloured by chain, top view.
Source organism: Schistosoma mansoni
Primary publication:
Molecular basis for hycanthone drug action in schistosome parasites.
Guzman M, Rugel A, Tarpley RS, Cao X, McHardy SF, LoVerde PT, Taylor AB
Mol Biochem Parasitol 236 111257 (2020)
PMID: 32027942

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124461 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sulfotransferase oxamniquine resistance protein Chain: A
Molecule details ›
Chain: A
Length: 259 amino acids
Theoretical weight: 30.08 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: G4VLE5 (Residues: 1-257; Coverage: 100%)
Gene names: SULT-OR, Smp_089320
Sequence domains: Sulfotransferase domain

Ligands and Environments

2 bound ligands:
Ligand A3P 1 x A3P
Ligand QHM 1 x QHM
1 modified residue:
Ligand CAS 1 x CAS

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21212
Unit cell:
a: 139.62Å b: 39.3Å c: 54.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.169 0.209
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

From Steroid and Drug Metabolism to Glycobiology, Using Sulfotransferase Structures to Understand and Tailor Function.
Pedersen et al. (2022)
5 other articles