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Structure of ACLY in the presence of citrate and CoA

Source organism: Homo sapiens
Biochemical function: acyltransferase activity, acyl groups converted into alkyl on transfer
Biological process: coenzyme A metabolic process
Cellular component: ficolin-1-rich granule lumen

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EC 2.3.3.8: ATP citrate synthase

Reaction catalysed:
ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA
Systematic name:
Acetyl-CoA:oxaloacetate C-acetyltransferase ((pro-S)-carboxymethyl-forming, ADP-phosphorylating)
Alternative Name(s):
  • ATP citrate (pro-S)-lyase
  • ATP-citrate (pro-S-)-lyase
  • ATP-citric lyase
  • ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP-dephosphorylating)
  • Acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)
  • Adenosine triphosphate citrate lyase
  • Citrate cleavage enzyme
  • Citrate-ATP lyase
  • Citric cleavage enzyme

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00285
Domain description: Citrate synthase, C-terminal domain
Occurring in:
  1. ATP-citrate synthase
The deposited structure of PDB entry 6uuz contains 4 copies of Pfam domain PF00285 (Citrate synthase, C-terminal domain) in ATP-citrate synthase. Showing 1 copy in chain A.

PF00549
Domain description: CoA-ligase
Occurring in:
  1. ATP-citrate synthase
The deposited structure of PDB entry 6uuz contains 4 copies of Pfam domain PF00549 (CoA-ligase) in ATP-citrate synthase. Showing 1 copy in chain A.

PF02629
Domain description: CoA binding domain
Occurring in:
  1. ATP-citrate synthase
The deposited structure of PDB entry 6uuz contains 4 copies of Pfam domain PF02629 (CoA binding domain) in ATP-citrate synthase. Showing 1 copy in chain A.

PF16114
Domain description: ATP citrate lyase citrate-binding
Occurring in:
  1. ATP-citrate synthase
The deposited structure of PDB entry 6uuz contains 4 copies of Pfam domain PF16114 (ATP citrate lyase citrate-binding) in ATP-citrate synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016102
Domain description: Succinyl-CoA synthetase-like
Occurring in:
  1. ATP-citrate synthase
IPR003781
Domain description: CoA-binding
Occurring in:
  1. ATP-citrate synthase
IPR002020
Domain description: Citrate synthase
Occurring in:
  1. ATP-citrate synthase
IPR016143
Domain description: Citrate synthase-like, small alpha subdomain
Occurring in:
  1. ATP-citrate synthase
IPR017440
Domain description: ATP-citrate lyase/succinyl-CoA ligase, active site
Occurring in:
  1. ATP-citrate synthase
IPR033847
Domain description: ATP-citrate lyase/succinyl-CoA ligase, conserved site
Occurring in:
  1. ATP-citrate synthase
IPR005811
Domain description: ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain
Occurring in:
  1. ATP-citrate synthase
IPR036969
Domain description: Citrate synthase superfamily
Occurring in:
  1. ATP-citrate synthase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. ATP-citrate synthase
IPR017866
Domain description: Succinyl-CoA synthetase, beta subunit, conserved site
Occurring in:
  1. ATP-citrate synthase
IPR032263
Domain description: ATP-citrate synthase, citrate-binding domain
Occurring in:
  1. ATP-citrate synthase
IPR014608
Domain description: ATP-citrate synthase
Occurring in:
  1. ATP-citrate synthase

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