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Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1)

Electron Microscopy
3.7Å resolution
PDB entry 6v3f coloured by chain, front view.
PDB entry 6v3f coloured by chain, side view.
PDB entry 6v3f coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: NPC1-like intracellular cholesterol transporter 1
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Multimeric state: monomeric
Accessible surface area: 61748.81 Å2
Buried surface area: 4703.58 Å2
Dissociation area: 452.34 Å2
Dissociation energy (ΔGdiss): -3.83 kcal/mol
Dissociation entropy (TΔSdiss): 4.69 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-180351

Macromolecules

NPC1-like intracellular cholesterol transporter 1
Chain: A
Length: 1336 amino acids
Theoretical weight: 147.64 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6T3U3 (Residues: 21-1331; Coverage: 100%)
Gene name: Npc1l1
Pfam:
InterPro:
NPC1-like intracellular cholesterol transporter 1 in PDB entry 6v3f, assembly 1, front view.
NPC1-like intracellular cholesterol transporter 1 in PDB entry 6v3f, assembly 1, side view.
NPC1-like intracellular cholesterol transporter 1 in PDB entry 6v3f, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q6T3U3  
113361002003004005006007008009001,0001,1001,2001,300
 
5001000
UniProt
Q6T3U3
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Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Sequence conservation
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