› 6v3h

Electron Microscopy
3.5Å resolution

Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) in complex with an ezetimibe analog

Released:
DOI: 10.2210/pdb6v3h/pdb
PDB entry 6v3h coloured by chain, front view.
PDB entry 6v3h coloured by chain, side view.
PDB entry 6v3h coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition
Huang CS, Yu X, Fordstrom P, Choi K, Chung BC, Roh SH, Chiu W, Zhou M, Min X, Wang Z
Sci Adv 6 eabb1989- (2020)
Related structures: EMD-21037

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180351 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
NPC1-like intracellular cholesterol transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 1336 amino acids
Theoretical weight: 147.64 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6T3U3 (Residues: 21-1331; Coverage: 100%)
Gene name: Npc1l1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 6 x NAG
Ligand Y01 2 x Y01
Ligand QO1 1 x QO1
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-21037
Expression system: Homo sapiens

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