› 6v6b

Electron Microscopy
3.8Å resolution

Structures of GCP2 and GCP3 in the native human gamma-tubulin ring complex

Released:
DOI: 10.2210/pdb6v6b/pdb
PDB entry 6v6b coloured by chain, front view.
PDB entry 6v6b coloured by chain, side view.
PDB entry 6v6b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Asymmetric Molecular Architecture of the Human γ-Tubulin Ring Complex.
Wieczorek M, Urnavicius L, Ti SC, Molloy KR, Chait BT, Kapoor TM
Cell 180 165-175.e16 (2020)
PMID: 31862189
Related structures: EMD-21067

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188423 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Gamma-tubulin complex component 3 Chain: B
Molecule details ›
Chain: B
Length: 907 amino acids
Theoretical weight: 103.71 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96CW5 (Residues: 1-907; Coverage: 100%)
Gene names: GCP3, TUBGCP3
Sequence domains:
Gamma-tubulin complex component 2 Chain: C
Molecule details ›
Chain: C
Length: 930 amino acids
Theoretical weight: 105.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BSJ2 (Residues: 1-205, 206-902; Coverage: 100%)
  • Best match: Q9BSJ2-4 (Residues: 1-930)
Gene names: GCP2, TUBGCP2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-21067

Quick links

Citations

16 review citations

Mechanisms of microtubule organization in differentiated animal cells.
Akhmanova et al. (2022)
15 more

3 mentions without citation

Asymmetric Molecular Architecture of the Human γ-Tubulin Ring Complex.
Wieczorek et al. (2020)
2 more