› 6v6t

Solution NMR

Solution structure of delta-theraphotoxin-Hm1b from Heteroscodra maculata

Released:
DOI: 10.2210/pdb6v6t/pdb
PDB entry 6v6t coloured by chain, ensemble of 20 models, front view.
PDB entry 6v6t coloured by chain, ensemble of 20 models, side view.
PDB entry 6v6t coloured by chain, ensemble of 20 models, top view.
Source organism: Heteroscodra maculata
Primary publication:
A selective NaV1.1 activator with potential for treatment of Dravet syndrome epilepsy.
Chow CY, Chin YKY, Ma L, Undheim EAB, Herzig V, King GF
Biochem Pharmacol 181 113991 (2020)
PMID: 32335140

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143659 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Delta-theraphotoxin-Hm1b Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 3.99 KDa
Source organism: Heteroscodra maculata
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DOC5 (Residues: 1-34; Coverage: 100%)
Sequence domains: Ion channel inhibitory toxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 83%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

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Citations

6 review citations

Animal toxins - Nature's evolutionary-refined toolkit for basic research and drug discovery.
Herzig et al. (2020)
5 more