Function and Biology Details
Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
E3 ubiquitin-protein ligase UHRF1 (preferred)
PDBe Complex ID:
PDB-CPX-186561 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase UHRF1
Molecule details ›
Chain: A
Length: 187 amino acids
Theoretical weight: 21.69 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains: Tandem tudor domain within UHRF1
Length: 187 amino acids
Theoretical weight: 21.69 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical:
Q8VDF2 (Residues: 122-305; Coverage: 24%)
Sequence domains: Tandem tudor domain within UHRF1
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment:
74%
Refinement method:
molecular dynamics
Expression system: Escherichia coli
