› 6vfq

X-ray diffraction
2.3Å resolution

Crystal structure of monomeric human protocadherin 10 EC1-EC4

Released:
DOI: 10.2210/pdb6vfq/pdb
PDB entry 6vfq coloured by chain, front view.
PDB entry 6vfq coloured by chain, side view.
PDB entry 6vfq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins.
Harrison OJ, Brasch J, Katsamba PS, Ahlsen G, Noble AJ, Dan H, Sampogna RV, Potter CS, Carragher B, Honig B, Shapiro L
OpenAccess logo Cell Rep 30 2655-2671.e7 (2020)
PMID: 32101743

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192836 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Protocadherin-10 Chain: A
Molecule details ›
Chain: A
Length: 444 amino acids
Theoretical weight: 48.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9P2E7 (Residues: 18-455; Coverage: 43%)
Gene names: KIAA1400, PCDH10
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
4 bound ligands:
Ligand CA 9 x CA
Ligand MAN 2 x MAN
Ligand ACT 1 x ACT
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 26.373Å b: 78.91Å c: 238.886Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.188 0.237
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition.
Honig et al. (2020)
3 more

1 mention without citation

Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins.
Harrison et al. (2020)