› 6vgh

X-ray diffraction
2.1Å resolution

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant In Complex with Lasofoxifene

Released:
DOI: 10.2210/pdb6vgh/pdb
PDB entry 6vgh coloured by chain, front view.
PDB entry 6vgh coloured by chain, side view.
PDB entry 6vgh coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Fanning SW, Greene GL

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136919 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 262 amino acids
Theoretical weight: 30.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 307-554; Coverage: 42%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand C3D 2 x C3D
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P65
Unit cell:
a: 58.692Å b: 58.692Å c: 276.475Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.216 0.274
Expression system: Escherichia coli

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