› 6vin

X-ray diffraction
3.04Å resolution

Crystallographic structure of the circularly permuted human Taspase1 protein

Released:
DOI: 10.2210/pdb6vin/pdb
PDB entry 6vin coloured by chain, front view.
PDB entry 6vin coloured by chain, side view.
PDB entry 6vin coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the function of the catalytically active human Taspase1.
Nagaratnam N, Delker SL, Jernigan R, Edwards TE, Snider J, Thifault D, Williams D, Nannenga BL, Stofega M, Sambucetti L, Hsieh JJ, Flint AJ, Fromme P, Martin-Garcia JM
Structure 29 873-885.e5 (2021)
PMID: 33784495

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Threonine aspartase subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 389 amino acids
Theoretical weight: 41.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H6P5 (Residues: 41-233; Coverage: 46%)
  • Best match: Q9H6P5-3 (Residues: 41-95)
Gene names: C20orf13, TASP1
Sequence domains: Asparaginase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: R32
Unit cell:
a: 196Å b: 196Å c: 196.91Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.237 0.307
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 citation in other articles

Closantel is an allosteric inhibitor of human Taspase1.
Luciano et al. (2021)
2 more