› 6vk2

Solution NMR

NMR solution structure of Grb2-SH2 domain at pH 7

Released:
DOI: 10.2210/pdb6vk2/pdb
PDB entry 6vk2 coloured by chain, ensemble of 20 models, front view.
PDB entry 6vk2 coloured by chain, ensemble of 20 models, side view.
PDB entry 6vk2 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The dynamics of free and phosphopeptide-bound Grb2-SH2 reveals two dynamically independent subdomains and an encounter complex with fuzzy interactions.
Sanches K, Caruso IP, Almeida FCL, Melo FA
OpenAccess logo Sci Rep 10 13040 (2020)
PMID: 32747626

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158852 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth factor receptor-bound protein 2 Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 11.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62993 (Residues: 55-150; Coverage: 44%)
Gene names: ASH, GRB2
Sequence domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: na
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Protein Surface Interactions-Theoretical and Experimental Studies.
Almeida et al. (2021)
2 other articles

1 mention without citation

The dynamics of free and phosphopeptide-bound Grb2-SH2 reveals two dynamically independent subdomains and an encounter complex with fuzzy interactions.
Sanches et al. (2020)