› 6vto

X-ray diffraction
1.69Å resolution

Crystal structure of human Galectin-7 in complex with 4-O-beta-D-Galactopyranosyl-D-glucose

Released:
DOI: 10.2210/pdb6vto/pdb
PDB entry 6vto coloured by chain, front view.
PDB entry 6vto coloured by chain, side view.
PDB entry 6vto coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7.
Pham NTH, Létourneau M, Fortier M, Bégin G, Al-Abdul-Wahid MS, Pucci F, Folch B, Rooman M, Chatenet D, St-Pierre Y, Lagüe P, Calmettes C, Doucet N
OpenAccess logo J Biol Chem 297 101308 (2021)
PMID: 34673030

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155680 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 135 amino acids
Theoretical weight: 14.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P47929 (Residues: 2-136; Coverage: 99%)
Gene names: LGALS7, LGALS7B, PIG1
Sequence domains: Galactoside-binding lectin

Ligands and Environments

1 bound ligand:
Ligand LBL 2 x LBL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08B1-1
Spacegroup: P212121
Unit cell:
a: 30.52Å b: 77.24Å c: 111.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.183 0.215
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Galectin functions in cancer-associated inflammation and thrombosis.
Kruk et al. (2023)
1 more

1 mention without citation

Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7.
Pham et al. (2021)