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Structure of nevanimibe-bound human tetrameric ACAT1

Source organism: Homo sapiens
Biochemical function: cholesterol O-acyltransferase activity
Biological process: positive regulation of amyloid precursor protein biosynthetic process
Cellular component: membrane

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EC 2.3.1.26: Sterol O-acyltransferase

Reaction catalysed:
A long-chain acyl-CoA + a sterol = CoA + a long-chain 3-hydroxysterol ester
Systematic name:
Long-chain acyl-CoA:sterol O-acyltransferase
Alternative Name(s):
  • ACAT
  • Acyl coenzyme A-cholesterol-O-acyltransferase
  • Acyl-CoA:cholesterol O-acyltransferase
  • Acyl-CoA:cholesterol acyltransferase
  • Acylcoenzyme A:cholesterol O-acyltransferase
  • Cholesterol acyltransferase
  • Cholesterol ester synthase
  • Cholesterol ester synthetase
  • Cholesteryl ester synthetase
  • Sterol-ester synthase
  • Sterol-ester synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF03062
Domain description: MBOAT, membrane-bound O-acyltransferase family
Occurring in:
  1. Sterol O-acyltransferase 1
The deposited structure of PDB entry 6vum contains 4 copies of Pfam domain PF03062 (MBOAT, membrane-bound O-acyltransferase family) in Sterol O-acyltransferase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR014371
Domain description: Sterol O-acyltransferase, ACAT/DAG/ARE types
Occurring in:
  1. Sterol O-acyltransferase 1
IPR004299
Domain description: Membrane bound O-acyl transferase, MBOAT
Occurring in:
  1. Sterol O-acyltransferase 1
IPR030687
Domain description: Sterol O-acyltransferase, metazoa
Occurring in:
  1. Sterol O-acyltransferase 1

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