Function and Biology

Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB300

Source organism: Mycobacterium tuberculosis H37Ra
Biochemical function: NADP binding
Biological process: folic acid metabolic process
Cellular component: cytosol

EC 1.5.1.3: Dihydrofolate reductase

Reaction catalysed:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH
Systematic name:
5,6,7,8-tetrahydrofolate:NADP(+) oxidoreductase
Alternative Name(s):
  • 7,8-dihydrofolate reductase
  • DHFR
  • Dihydrofolate reductase:thymidylate synthase
  • Dihydrofolic acid reductase
  • Dihydrofolic reductase
  • Folic acid reductase
  • Folic reductase
  • NADPH-dihydrofolate reductase
  • Pteridine reductase:dihydrofolate reductase
  • Tetrahydrofolate dehydrogenase
  • Thymidylate synthetase-dihydrofolate reductase

Sequence family

Pfam Protein family (Pfam)
PF00186
Domain description: Dihydrofolate reductase
Occurring in:
  1. Dihydrofolate reductase
The deposited structure of PDB entry 6vv9 contains 2 copies of Pfam domain PF00186 (Dihydrofolate reductase) in Dihydrofolate reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001796
Domain description: Dihydrofolate reductase domain
Occurring in:
  1. Dihydrofolate reductase
IPR024072
Domain description: Dihydrofolate reductase-like domain superfamily
Occurring in:
  1. Dihydrofolate reductase
IPR012259
Domain description: Dihydrofolate reductase
Occurring in:
  1. Dihydrofolate reductase
IPR017925
Domain description: Dihydrofolate reductase conserved site
Occurring in:
  1. Dihydrofolate reductase