› 6vyf

Electron Microscopy
3.3Å resolution

Cryo-EM structure of Plasmodium vivax hexokinase (Open state)

Released:
DOI: 10.2210/pdb6vyf/pdb
PDB entry 6vyf coloured by chain, front view.
PDB entry 6vyf coloured by chain, side view.
PDB entry 6vyf coloured by chain, top view.
Source organism: Plasmodium vivax
Primary publication:
Plasmodium vivax and human hexokinases share similar active sites but display distinct quaternary architectures
Srivastava SS, Darling JE, Suryadi J, Morris JC, Drew ME, Subramaniam S
IUCrJ 7 453-461 (2020)
Related structures: EMD-21458

Function and Biology Details

Reaction catalysed: 
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107659 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphotransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 505 amino acids
Theoretical weight: 56.85 KDa
Source organism: Plasmodium vivax
Expression system: Escherichia coli
UniProt:
  • Canonical: A5K274 (Residues: 1-493; Coverage: 100%)
Gene name: PVX_114315
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-21458
Expression system: Escherichia coli

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