› 6vyh

Electron Microscopy
3Å resolution

Cryo-EM structure of SLC40/ferroportin in complex with Fab

Released:
DOI: 10.2210/pdb6vyh/pdb
PDB entry 6vyh coloured by chain, front view.
PDB entry 6vyh coloured by chain, side view.
PDB entry 6vyh coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of ion transport and inhibition in ferroportin.
Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M
OpenAccess logo Nat Commun 11 5686 (2020)
PMID: 33173040
Related structures: EMD-21460

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-224591 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Solute carrier family 40 member Chain: A
Molecule details ›
Chain: A
Length: 577 amino acids
Theoretical weight: 63.71 KDa
Source organism: Carlito syrichta
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A1U7U6F1 (Residues: 1-572; Coverage: 100%)
Gene name: SLC40A1
Sequence domains: Ferroportin1 (FPN1)
11F9 light-chain Chain: C
Molecule details ›
Chain: C
Length: 213 amino acids
Theoretical weight: 23.49 KDa
Source organism: Mus musculus
11F9 heavy-chain Chain: D
Molecule details ›
Chain: D
Length: 238 amino acids
Theoretical weight: 25.82 KDa
Source organism: Mus musculus

Ligands and Environments

1 bound ligand:
Ligand CO 2 x CO
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-21460
Expression system: Trichoplusia ni

Quick links

Citations

9 review citations

Iron metabolism in infections: Focus on COVID-19.
Girelli et al. (2021)
8 more

6 mentions without citation

Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS).
Drew et al. (2021)
5 more