› 6vzk

X-ray diffraction
2.55Å resolution

Crystal structure of human CaMKII-alpha (CAMK2A)kinase domain

Released:
DOI: 10.2210/pdb6vzk/pdb
PDB entry 6vzk coloured by chain, front view.
PDB entry 6vzk coloured by chain, side view.
PDB entry 6vzk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Characterization of CaMKIIα holoenzyme stability.
Torres-Ocampo AP, Özden C, Hommer A, Gardella A, Lapinskas E, Samkutty A, Esposito E, Garman SC, Stratton MM
Protein Sci 29 1524-1534 (2020)
PMID: 32282091

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-577754 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 268 amino acids
Theoretical weight: 30.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UQM7 (Residues: 7-274; Coverage: 56%)
Gene names: CAMK2A, CAMKA, KIAA0968
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand HC4 1 x HC4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 48.147Å b: 56.928Å c: 97.461Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.21 0.294
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Scattering-based Light Microscopy: From Metal Nanoparticles to Single Proteins.
Priest et al. (2021)
3 more

2 mentions without citation

Characterization of CaMKIIα holoenzyme stability.
Torres-Ocampo et al. (2020)
1 more