› 6w19

Electron Microscopy
5.5Å resolution

Structures of Capsid and Capsid-Associated Tegument Complex inside the Epstein-Barr Virus

Released:
DOI: 10.2210/pdb6w19/pdb
PDB entry 6w19 coloured by chain, front view.
PDB entry 6w19 coloured by chain, side view.
PDB entry 6w19 coloured by chain, top view.
Source organism: Human herpesvirus 4 strain B95-8
Primary publication:
Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus.
Liu W, Cui Y, Wang C, Li Z, Gong D, Dai X, Bi GQ, Sun R, Zhou ZH
Nat Microbiol 5 1285-1298 (2020)
PMID: 32719506
Related structures: EMD-21504

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 3000-mer (preferred)
PDBe Complex ID:
PDB-CPX-136641 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Major capsid protein Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 1381 amino acids
Theoretical weight: 154.09 KDa
Source organism: Human herpesvirus 4 strain B95-8
UniProt:
  • Canonical: P03226 (Residues: 1-1381; Coverage: 100%)
Gene names: BcLF1, MCP
Sequence domains: Herpes virus major capsid protein
Small capsomere-interacting protein Chains: Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, u
Molecule details ›
Chains: Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, u
Length: 176 amino acids
Theoretical weight: 18.17 KDa
Source organism: Human herpesvirus 4 strain B95-8
UniProt:
  • Canonical: P14348 (Residues: 1-176; Coverage: 100%)
Gene names: BFRF3, SCP
Sequence domains: Gammaherpesvirus capsid protein
Triplex capsid protein 1 Chains: 1, f, g, h, i, j
Molecule details ›
Chains: 1, f, g, h, i, j
Length: 364 amino acids
Theoretical weight: 39.23 KDa
Source organism: Human herpesvirus 4 strain B95-8
UniProt:
  • Canonical: P03187 (Residues: 1-364; Coverage: 100%)
Gene names: BORF1, TRX1
Sequence domains: Herpesvirus capsid shell protein VP19C
Triplex capsid protein 2 Chains: 2, 3, k, l, m, n, o, p, q, r, s, t
Molecule details ›
Chains: 2, 3, k, l, m, n, o, p, q, r, s, t
Length: 301 amino acids
Theoretical weight: 33.65 KDa
Source organism: Human herpesvirus 4 strain B95-8
UniProt:
  • Canonical: P25214 (Residues: 1-301; Coverage: 100%)
Gene names: BDLF1, TRX2
Sequence domains: Herpesvirus VP23 like capsid protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.5Å
Relevant EMDB volumes: EMD-21504

Quick links

Citations

4 review citations

The Ins and Outs of Herpesviral Capsids: Divergent Structures and Assembly Mechanisms across the Three Subfamilies.
Draganova et al. (2021)
3 more

1 mention without citation

Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus.
Liu et al. (2020)