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ClpAP Engaged2 State bound to RepA-GFP

Source organisms:
Biochemical function: protein binding
Biological process: protein quality control for misfolded or incompletely synthesized proteins
Cellular component: endopeptidase Clp complex

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EC 3.4.21.92: Endopeptidase Clp

Reaction catalysed:
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-Casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
Systematic name:
-
Alternative Name(s):
  • ATP-dependent Clp protease
  • Caseinolytic protease
  • Clp protease
  • ClpP
  • Endopeptidase Ti
  • Protease Ti

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00574
Domain description: Clp protease
Occurring in:
  1. ATP-dependent Clp protease proteolytic subunit
The deposited structure of PDB entry 6w21 contains 14 copies of Pfam domain PF00574 (Clp protease) in ATP-dependent Clp protease proteolytic subunit. Showing 1 copy in chain H [auth G].

PF10431
Domain description: C-terminal, D2-small domain, of ClpB protein
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
The deposited structure of PDB entry 6w21 contains 6 copies of Pfam domain PF10431 (C-terminal, D2-small domain, of ClpB protein ) in ATP-dependent Clp protease ATP-binding subunit ClpA. Showing 1 copy in chain B.

PF07724
Domain description: AAA domain (Cdc48 subfamily)
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
The deposited structure of PDB entry 6w21 contains 6 copies of Pfam domain PF07724 (AAA domain (Cdc48 subfamily)) in ATP-dependent Clp protease ATP-binding subunit ClpA. Showing 1 copy in chain B.

PF17871
Domain description: AAA lid domain
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
The deposited structure of PDB entry 6w21 contains 6 copies of Pfam domain PF17871 (AAA lid domain) in ATP-dependent Clp protease ATP-binding subunit ClpA. Showing 1 copy in chain B.

PF00004
Domain description: ATPase family associated with various cellular activities (AAA)
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
The deposited structure of PDB entry 6w21 contains 6 copies of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in ATP-dependent Clp protease ATP-binding subunit ClpA. Showing 1 copy in chain B.

PF02861
Domain description: Clp amino terminal domain, pathogenicity island component
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
The deposited structure of PDB entry 6w21 contains 6 copies of Pfam domain PF02861 (Clp amino terminal domain, pathogenicity island component) in ATP-dependent Clp protease ATP-binding subunit ClpA. Showing 1 copy in chain B (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR001907
Domain description: ATP-dependent Clp protease proteolytic subunit
Occurring in:
  1. ATP-dependent Clp protease proteolytic subunit
IPR023562
Domain description: Clp protease proteolytic subunit /Translocation-enhancing protein TepA
Occurring in:
  1. ATP-dependent Clp protease proteolytic subunit
IPR001270
Domain description: ClpA/B family
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
IPR033135
Domain description: ClpP, histidine active site
Occurring in:
  1. ATP-dependent Clp protease proteolytic subunit
IPR018215
Domain description: ClpP, Ser active site
Occurring in:
  1. ATP-dependent Clp protease proteolytic subunit
IPR029045
Domain description: ClpP/crotonase-like domain superfamily
Occurring in:
  1. ATP-dependent Clp protease proteolytic subunit
IPR019489
Domain description: Clp ATPase, C-terminal
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
IPR003959
Domain description: ATPase, AAA-type, core
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
IPR036628
Domain description: Clp, N-terminal domain superfamily
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
IPR004176
Domain description: Clp, repeat (R) domain
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
IPR028299
Domain description: ClpA/B, conserved site 2
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
IPR041546
Domain description: ClpA/ClpB, AAA lid domain
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
IPR018368
Domain description: ClpA/B, conserved site 1
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA
IPR013461
Domain description: ATP-dependent Clp protease ATP-binding subunit ClpA
Occurring in:
  1. ATP-dependent Clp protease ATP-binding subunit ClpA

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