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The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with a locally refined ClpB middle domain and a DnaK nucleotide binding domain

Source organism: Mycobacterium tuberculosis
Biochemical function: ATP hydrolysis activity
Biological process: protein refolding
Cellular component: peptidoglycan-based cell wall

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF02861
Domain description: Clp amino terminal domain, pathogenicity island component
Occurring in:
  1. Chaperone protein ClpB
The deposited structure of PDB entry 6w6e contains 12 copies of Pfam domain PF02861 (Clp amino terminal domain, pathogenicity island component) in Chaperone protein ClpB. Showing 2 copies in chain A (this domain is out of the observed residue ranges!).

PF10431
Domain description: C-terminal, D2-small domain, of ClpB protein
Occurring in:
  1. Chaperone protein ClpB
The deposited structure of PDB entry 6w6e contains 6 copies of Pfam domain PF10431 (C-terminal, D2-small domain, of ClpB protein ) in Chaperone protein ClpB. Showing 1 copy in chain A.

PF07724
Domain description: AAA domain (Cdc48 subfamily)
Occurring in:
  1. Chaperone protein ClpB
The deposited structure of PDB entry 6w6e contains 6 copies of Pfam domain PF07724 (AAA domain (Cdc48 subfamily)) in Chaperone protein ClpB. Showing 1 copy in chain A.

PF17871
Domain description: AAA lid domain
Occurring in:
  1. Chaperone protein ClpB
The deposited structure of PDB entry 6w6e contains 6 copies of Pfam domain PF17871 (AAA lid domain) in Chaperone protein ClpB. Showing 1 copy in chain A.

PF00004
Domain description: ATPase family associated with various cellular activities (AAA)
Occurring in:
  1. Chaperone protein ClpB
The deposited structure of PDB entry 6w6e contains 6 copies of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in Chaperone protein ClpB. Showing 1 copy in chain A.

PF00012
Domain description: Hsp70 protein
Occurring in:
  1. Chaperone protein DnaK
The deposited structure of PDB entry 6w6e contains 1 copy of Pfam domain PF00012 (Hsp70 protein) in Chaperone protein DnaK. Showing 1 copy in chain G [auth I].

InterPro InterPro annotations
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Chaperone protein ClpB
IPR001270
Domain description: ClpA/B family
Occurring in:
  1. Chaperone protein ClpB
IPR004176
Domain description: Clp, repeat (R) domain
Occurring in:
  1. Chaperone protein ClpB
IPR019489
Domain description: Clp ATPase, C-terminal
Occurring in:
  1. Chaperone protein ClpB
IPR003959
Domain description: ATPase, AAA-type, core
Occurring in:
  1. Chaperone protein ClpB
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Chaperone protein ClpB
IPR036628
Domain description: Clp, N-terminal domain superfamily
Occurring in:
  1. Chaperone protein ClpB
IPR028299
Domain description: ClpA/B, conserved site 2
Occurring in:
  1. Chaperone protein ClpB
IPR041546
Domain description: ClpA/ClpB, AAA lid domain
Occurring in:
  1. Chaperone protein ClpB
IPR018368
Domain description: ClpA/B, conserved site 1
Occurring in:
  1. Chaperone protein ClpB
IPR017730
Domain description: Chaperonin ClpB
Occurring in:
  1. Chaperone protein ClpB
IPR018181
Domain description: Heat shock protein 70, conserved site
Occurring in:
  1. Chaperone protein DnaK
IPR013126
Domain description: Heat shock protein 70 family
Occurring in:
  1. Chaperone protein DnaK
IPR029048
Domain description: Heat shock protein 70kD, C-terminal domain superfamily
Occurring in:
  1. Chaperone protein DnaK
IPR029047
Domain description: Heat shock protein 70kD, peptide-binding domain superfamily
Occurring in:
  1. Chaperone protein DnaK
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Chaperone protein DnaK
IPR012725
Domain description: Chaperone DnaK
Occurring in:
  1. Chaperone protein DnaK

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