› 6w9n

Solution NMR

Solution structure of the FYVE domain of ALFY

Released:
DOI: 10.2210/pdb6w9n/pdb
PDB entry 6w9n coloured by chain, ensemble of 20 models, front view.
PDB entry 6w9n coloured by chain, ensemble of 20 models, side view.
PDB entry 6w9n coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance.
Reinhart EF, Litt NA, Katzenell S, Pellegrini M, Yamamoto A, Ragusa MJ
Traffic 22 23-37 (2021)
PMID: 33225481

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184973 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat and FYVE domain-containing protein 3 Chain: A
Molecule details ›
Chain: A
Length: 78 amino acids
Theoretical weight: 8.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IZQ1 (Residues: 3444-3518; Coverage: 2%)
Gene names: KIAA0993, WDFY3
Sequence domains: FYVE zinc finger

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 82%
Refinement method: na
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The evolving biology of cross-presentation.
Ohara et al. (2023)
3 other articles

1 mention without citation

A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance.
Reinhart et al. (2021)