› 6wbl

Electron Microscopy
5.13Å resolution

Cryo-EM structure of human Pannexin 1 channel with deletion of N-terminal helix and C-terminal tail, in complex with CBX

Released:
DOI: 10.2210/pdb6wbl/pdb
PDB entry 6wbl coloured by chain, front view.
PDB entry 6wbl coloured by chain, side view.
PDB entry 6wbl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Ruan Z, Orozco IJ, Du J, Lü W
Nature 584 646-651 (2020)
PMID: 32494015
Related structures: EMD-21592

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188716 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase-activated pannexin-1 Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 370 amino acids
Theoretical weight: 41.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96RD7 (Residues: 1-370; Coverage: 87%)
Gene names: MRS1, PANX1, UNQ2529/PRO6028
Sequence domains: Innexin

Ligands and Environments

1 bound ligand:
Ligand CBO 1 x CBO
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.13Å
Relevant EMDB volumes: EMD-21592
Expression system: Homo sapiens

Quick links

Citations

20 review citations

Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters.
Moroz et al. (2021)
19 more

2 mentions without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
1 more