› 6wg2

X-ray diffraction
2.53Å resolution

Crystal structure of Fab239 in complex with NPNA4 peptide from circumsporozoite protein

Released:
DOI: 10.2210/pdb6wg2/pdb
PDB entry 6wg2 coloured by chain, front view.
PDB entry 6wg2 coloured by chain, side view.
PDB entry 6wg2 coloured by chain, top view.
Source organisms:
Primary publication:
Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Pholcharee T, Oyen D, Flores-Garcia Y, Gonzalez-Paez G, Han Z, Williams KL, Volkmuth W, Emerling D, Locke E, Richter King C, Zavala F, Wilson IA
OpenAccess logo Nat Commun 12 1063 (2021)
PMID: 33594061

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-527078 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab239 heavy chain Chains: H, I
Molecule details ›
Chains: H, I
Length: 224 amino acids
Theoretical weight: 24.2 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Fab239 light chain Chains: L, M
Molecule details ›
Chains: L, M
Length: 215 amino acids
Theoretical weight: 23.61 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Circumsporozoite protein Chain: P
Molecule details ›
Chain: P
Length: 18 amino acids
Theoretical weight: 1.63 KDa
Source organism: Plasmodium falciparum
Expression system: Not provided
UniProt:
  • Canonical: P02893 (Residues: 270-285; Coverage: 4%)
Gene name: CSP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21
Unit cell:
a: 82.166Å b: 55.706Å c: 115.732Å
α: 90° β: 98.89° γ: 90°
R-values:
R R work R free
0.197 0.194 0.246
Expression systems:
  • Cricetulus griseus
  • Not provided

Quick links

Citations

5 review citations

RTS,S: the first malaria vaccine.
Zavala F. (2022)
4 more