› 6whk

X-ray diffraction
2.6Å resolution

Minimally mutated anti-influenza broadly neutralizing antibody

Released:
DOI: 10.2210/pdb6whk/pdb
PDB entry 6whk coloured by chain, front view.
PDB entry 6whk coloured by chain, side view.
PDB entry 6whk coloured by chain, top view.
Source organisms:
Entry authors: Bajic G, Schmidt AG

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-207674 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Hemagglutinin HA1 chain Chain: A
Molecule details ›
Chain: A
Length: 230 amino acids
Theoretical weight: 25.98 KDa
Source organism: Influenza A virus (A/Beijing/262/1995(H1N1))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: B4UPF7 (Residues: 61-280; Coverage: 39%)
Gene name: HA
Sequence domains: Haemagglutinin
Fab Heavy Chain Chain: C
Molecule details ›
Chain: C
Length: 240 amino acids
Theoretical weight: 25.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab Light Chain Chain: B
Molecule details ›
Chain: B
Length: 219 amino acids
Theoretical weight: 22.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand PE4 1 x PE4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 69.57Å b: 76.33Å c: 126.17Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.268
Expression systems:
  • Trichoplusia ni
  • Homo sapiens

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