› 6wi1

Electron Microscopy
3.62Å resolution

GluN1b-GluN2B NMDA receptor in active conformation stabilized by inter-GluN1b-GluN2B subunit cross-linking

Released:
DOI: 10.2210/pdb6wi1/pdb
PDB entry 6wi1 coloured by chain, front view.
PDB entry 6wi1 coloured by chain, side view.
PDB entry 6wi1 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural Basis of Functional Transitions in Mammalian NMDA Receptors.
Chou TH, Tajima N, Romero-Hernandez A, Furukawa H
Cell 182 357-371.e13 (2020)
PMID: 32610085
Related structures: EMD-21682

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152911 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Glutamate receptor ionotropic, NMDA 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 868 amino acids
Theoretical weight: 97.74 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35439 (Residues: 1-190, 191-847; Coverage: 90%)
  • Best match: P35439-2 (Residues: 1-868)
Gene names: Grin1, Nmdar1
Sequence domains:
Glutamate receptor ionotropic, NMDA 2B Chains: B, D
Molecule details ›
Chains: B, D
Length: 883 amino acids
Theoretical weight: 98.88 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q00960 (Residues: 25-852; Coverage: 57%)
Gene name: Grin2b
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.62Å
Relevant EMDB volumes: EMD-21682
Expression system: Spodoptera frugiperda

Quick links

Citations

7 review citations

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
6 more

4 mentions without citation

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
3 more