› 6wik

Electron Microscopy
3.4Å resolution

Cryo-EM structure of SLC40/ferroportin with Fab in the presence of hepcidin

Released:
DOI: 10.2210/pdb6wik/pdb
PDB entry 6wik coloured by chain, front view.
PDB entry 6wik coloured by chain, side view.
PDB entry 6wik coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of ion transport and inhibition in ferroportin.
Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M
Nat Commun 11 5686 (2020)
PMID: 33173040
Related structures: EMD-21684

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-224592 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
11F9 Fab light-chain Chain: C
Molecule details ›
Chain: C
Length: 213 amino acids
Theoretical weight: 23.49 KDa
Source organism: Mus musculus
11F9 Fab heavy-chain Chain: D
Molecule details ›
Chain: D
Length: 238 amino acids
Theoretical weight: 25.82 KDa
Source organism: Mus musculus
Solute carrier family 40 member Chain: A
Molecule details ›
Chain: A
Length: 577 amino acids
Theoretical weight: 63.71 KDa
Source organism: Carlito syrichta
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A1U7U6F1 (Residues: 1-572; Coverage: 100%)
Gene name: SLC40A1
Sequence domains: Ferroportin1 (FPN1)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-21684
Expression system: Trichoplusia ni

Quick links

Citations

9 review citations

Iron metabolism in infections: Focus on COVID-19.
Girelli et al. (2021)
8 more

1 mention without citation

Structural basis of ferroportin inhibition by minihepcidin PR73.
Wilbon et al. (2023)