Function and Biology Details
Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Histone-fold
- DNA polymerase epsilon, catalytic subunit A, C-terminal
- DNA polymerase family B, thumb domain
- DNA-directed DNA polymerase, family B, multifunctional domain
- DNA polymerase, palm domain superfamily
- DNA/RNA polymerase superfamily
- Ribonuclease H superfamily
- DNA-directed DNA polymerase, family B
5 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
DNA polymerase epsilon complex (preferred)
PDBe Complex ID:
PDB-CPX-149480 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
DNA polymerase epsilon catalytic subunit A
Molecule details ›
DNA polymerase epsilon subunit B
Molecule details ›
Chain: 2
Length: 689 amino acids
Theoretical weight: 78.43 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains: DNA polymerase alpha/epsilon subunit B
Length: 689 amino acids
Theoretical weight: 78.43 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
P24482 (Residues: 1-689; Coverage: 100%)
Sequence domains: DNA polymerase alpha/epsilon subunit B
DNA polymerase epsilon subunit C
Molecule details ›
Chain: 3
Length: 201 amino acids
Theoretical weight: 22.69 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Length: 201 amino acids
Theoretical weight: 22.69 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical: P27344 (Residues: 1-201; Coverage: 100%)
DNA polymerase epsilon subunit D
Molecule details ›
Chain: 4
Length: 196 amino acids
Theoretical weight: 22.03 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Length: 196 amino acids
Theoretical weight: 22.03 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical: Q04603 (Residues: 1-196; Coverage: 100%)
