› 6wlg

X-ray diffraction
3.11Å resolution

Ints3 C-terminal Domain

Released:
DOI: 10.2210/pdb6wlg/pdb
PDB entry 6wlg coloured by chain, front view.
PDB entry 6wlg coloured by chain, side view.
PDB entry 6wlg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for multifunctional roles of human Ints3 C-terminal domain.
Li J, Ma X, Banerjee S, Baruah S, Schnicker NJ, Roh E, Ma W, Liu K, Bode AM, Dong Z
OpenAccess logo J Biol Chem 296 100112
PMID: 33434574

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179336 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrator complex subunit 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 423 amino acids
Theoretical weight: 48.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q68E01 (Residues: 555-977; Coverage: 41%)
Gene names: C1orf193, C1orf60, INTS3

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: R3
Unit cell:
a: 234.854Å b: 234.854Å c: 47.567Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.263
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Integrator is a global promoter-proximal termination complex.
Wagner et al. (2023)
1 more

3 mentions without citation

Genomic regulation of transcription and RNA processing by the multitasking Integrator complex.
Welsh et al. (2023)
2 more