› 6wm0

Electron Microscopy
3.52Å resolution

TASK2 in MSP1D1 lipid nanodisc at pH 8.5

Released:
DOI: 10.2210/pdb6wm0/pdb
PDB entry 6wm0 coloured by chain, front view.
PDB entry 6wm0 coloured by chain, side view.
PDB entry 6wm0 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for pH gating of the two-pore domain K+ channel TASK2.
Li B, Rietmeijer RA, Brohawn SG
Nature 586 457-462 (2020)
PMID: 32999458
Related structures: EMD-21846

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191624 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 344 amino acids
Theoretical weight: 38.66 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9JK62 (Residues: 1-335; Coverage: 67%)
Gene name: Kcnk5
Sequence domains: Ion channel

Ligands and Environments

1 bound ligand:
Ligand K 5 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.52Å
Relevant EMDB volumes: EMD-21846
Expression system: Komagataella pastoris

Quick links

Citations

5 review citations

Molecular dynamics: a powerful tool for studying the medicinal chemistry of ion channel modulators.
Şterbuleac D. (2021)
4 more

3 mentions without citation

Structural Insights into the Mechanisms and Pharmacology of K2P Potassium Channels.
Natale et al. (2021)
2 more