6wol

X-ray diffraction
2.49Å resolution

Next generation monomeric IgG4 Fc bound to neonatal Fc receptor

Released:
Model geometry
Fit model/data

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-134885 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Immunoglobulin heavy constant gamma 4 Chain: H
Molecule details ›
Chain: H
Length: 209 amino acids
Theoretical weight: 23.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01861 (Residues: 117-325; Coverage: 53%)
  • Best match: P01861-1 (Residues: 117-326)
Gene name: IGHG4
Sequence domains: Immunoglobulin C1-set domain
IgG receptor FcRn large subunit p51 Chain: A
Molecule details ›
Chain: A
Length: 267 amino acids
Theoretical weight: 29.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P55899 (Residues: 24-290; Coverage: 78%)
Gene names: FCGRT, FCRN
Sequence domains:
Beta-2-microglobulin Chain: B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUL
No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: C2221
Unit cell:
a: 68.284Å b: 122.598Å c: 178.456Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.234 0.27
Expression system: Homo sapiens