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Pyruvate Kinase M2 mutant-S37D

Source organism: Homo sapiens
Biochemical function: histone H2AXY142 kinase activity
Biological process: positive regulation of cytoplasmic translation
Cellular component: ficolin-1-rich granule lumen

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EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

EC 2.7.10.2: Non-specific protein-tyrosine kinase

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Systematic name:
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Alternative Name(s):
  • ABL
  • ABL1
  • ABL2
  • ABLL
  • ACK1
  • ACK2
  • AGMX1
  • ARG
  • ATK
  • ATP:protein-tyrosine O-phosphotransferase
  • BLK
  • BMX
  • BRK
  • BTK
  • BTKL
  • Bmk
  • Bruton's tyrosine kinase
  • Bsk
  • CAKb
  • CHK
  • CSK
  • CTK
  • CYL
  • Cdgip
  • Cytoplasmic protein tyrosine kinase
  • EMT
  • ETK
  • FAK
  • FAK2
  • FER
  • FES
  • FGR
  • FPS
  • FRK
  • FYN
  • Fadk
  • Fert1/2
  • Focal adhesion kinase
  • HCK
  • HCTK
  • HYL
  • IMD1
  • ITK
  • IYK
  • JAK1
  • JAK2
  • JAK3
  • JTK1
  • JTK9
  • Janus kinase 1
  • Janus kinase 2
  • Janus kinase 3
  • L-JAK
  • LCK
  • LSK
  • LYN
  • MATK
  • Ntk
  • P60c-src protein tyrosine kinase
  • PKB
  • PSCTK
  • PSCTK1
  • PSCTK2
  • PSCTK4
  • PSCTK5
  • PTK2
  • PTK2B
  • PTK6
  • PYK2
  • Protein-tyrosine kinase
  • RAFTK
  • RAK
  • Rlk
  • SLK
  • SRC
  • SRC2
  • SRK
  • SRM
  • SRMS
  • STD
  • SYK
  • SYN
  • Sik
  • TEC
  • TNK1
  • TXK
  • TYK2
  • TYK3
  • Tck
  • Tsk
  • YES1
  • YK2
  • ZAP70

EC 2.7.1.40: Pyruvate kinase

Reaction catalysed:
ATP + pyruvate = ADP + phosphoenolpyruvate
Systematic name:
ATP:pyruvate 2-O-phosphotransferase
Alternative Name(s):
  • Phosphoenol transphosphorylase
  • Phosphoenolpyruvate kinase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF02887
Domain description: Pyruvate kinase, alpha/beta domain
Occurring in:
  1. Pyruvate kinase PKM
The deposited structure of PDB entry 6wp5 contains 4 copies of Pfam domain PF02887 (Pyruvate kinase, alpha/beta domain) in Pyruvate kinase PKM. Showing 1 copy in chain B [auth A].

PF00224
Domain description: Pyruvate kinase, barrel domain
Occurring in:
  1. Pyruvate kinase PKM
The deposited structure of PDB entry 6wp5 contains 4 copies of Pfam domain PF00224 (Pyruvate kinase, barrel domain) in Pyruvate kinase PKM. Showing 1 copy in chain B [auth A].

InterPro InterPro annotations
IPR001697
Domain description: Pyruvate kinase
Occurring in:
  1. Pyruvate kinase PKM
IPR036918
Domain description: Pyruvate kinase, C-terminal domain superfamily
Occurring in:
  1. Pyruvate kinase PKM
IPR015795
Domain description: Pyruvate kinase, C-terminal
Occurring in:
  1. Pyruvate kinase PKM
IPR018209
Domain description: Pyruvate kinase, active site
Occurring in:
  1. Pyruvate kinase PKM
IPR015806
Domain description: Pyruvate kinase, insert domain superfamily
Occurring in:
  1. Pyruvate kinase PKM
IPR011037
Domain description: Pyruvate kinase-like, insert domain superfamily
Occurring in:
  1. Pyruvate kinase PKM
IPR040442
Domain description: Pyruvate kinase-like domain superfamily
Occurring in:
  1. Pyruvate kinase PKM
IPR015793
Domain description: Pyruvate kinase, barrel
Occurring in:
  1. Pyruvate kinase PKM
IPR015813
Domain description: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
Occurring in:
  1. Pyruvate kinase PKM
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Pyruvate kinase PKM

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