› 6wr4

Electron Microscopy
2.9Å resolution

Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery

Released:
DOI: 10.2210/pdb6wr4/pdb
PDB entry 6wr4 coloured by chain, front view.
PDB entry 6wr4 coloured by chain, side view.
PDB entry 6wr4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery.
Guardia CM, Tan XF, Lian T, Rana MS, Zhou W, Christenson ET, Lowry AJ, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A
Cell Rep 31 107837 (2020)
PMID: 32610138
Related structures: EMD-21876

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182248 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Autophagy-related protein 9A Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 839 amino acids
Theoretical weight: 94.55 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7Z3C6 (Residues: 1-839; Coverage: 100%)
Gene names: APG9L1, ATG9A
Sequence domains: Autophagy protein ATG9

Ligands and Environments

1 bound ligand:
Ligand LMN 6 x LMN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-21876
Expression system: Homo sapiens

Quick links

Citations

23 review citations

Mechanisms of nonvesicular lipid transport.
Reinisch et al. (2021)
22 more

2 mentions without citation

Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery.
Guardia et al. (2020)
1 more