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Cryo-EM structure of VASH1-SVBP bound to microtubules

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: neuron differentiation
Cellular component: cytoplasm

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EC 3.4.17.17: Tubulinyl-Tyr carboxypeptidase

Reaction catalysed:
Cleavage of the -Glu-|-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr.
Systematic name:
-
Alternative Name(s):
  • Brain I carboxypeptidase
  • Carboxypeptidase-tubulin
  • Soluble carboxypeptidase
  • TTCPase
  • Tubulin carboxypeptidase
  • Tubulin-tyrosine carboxypeptidase
  • Tubulinyltyrosine carboxypeptidase
  • Tyrosinotubulin carboxypeptidase
  • Tyrosyltubulin carboxypeptidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03953
Domain description: Tubulin C-terminal domain
Occurring in:
  1. Tubulin alpha-1A chain
  2. Tubulin beta-3 chain
The deposited structure of PDB entry 6wsl contains 2 copies of Pfam domain PF03953 (Tubulin C-terminal domain) in Tubulin alpha-1A chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 6wsl contains 2 copies of Pfam domain PF03953 (Tubulin C-terminal domain) in Tubulin beta-3 chain. Showing 1 copy in chain B.

PF00091
Domain description: Tubulin/FtsZ family, GTPase domain
Occurring in:
  1. Tubulin alpha-1A chain
  2. Tubulin beta-3 chain
The deposited structure of PDB entry 6wsl contains 2 copies of Pfam domain PF00091 (Tubulin/FtsZ family, GTPase domain) in Tubulin alpha-1A chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 6wsl contains 2 copies of Pfam domain PF00091 (Tubulin/FtsZ family, GTPase domain) in Tubulin beta-3 chain. Showing 1 copy in chain B.

PF15674
Domain description: Coiled-coil domain-containing protein 23
Occurring in:
  1. Small vasohibin-binding protein
The deposited structure of PDB entry 6wsl contains 2 copies of Pfam domain PF15674 (Coiled-coil domain-containing protein 23) in Small vasohibin-binding protein. Showing 1 copy in chain D.

PF14822
Domain description: Vasohibin
Occurring in:
  1. Tubulinyl-Tyr carboxypeptidase 1
The deposited structure of PDB entry 6wsl contains 2 copies of Pfam domain PF14822 (Vasohibin) in Tubulinyl-Tyr carboxypeptidase 1. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR000217
Domain description: Tubulin
Occurring in:
  1. Tubulin alpha-1A chain
  2. Tubulin beta-3 chain
IPR002453
Domain description: Beta tubulin
Occurring in:
  1. Tubulin beta-3 chain
IPR002452
Domain description: Alpha tubulin
Occurring in:
  1. Tubulin alpha-1A chain
IPR018316
Domain description: Tubulin/FtsZ, 2-layer sandwich domain
Occurring in:
  1. Tubulin alpha-1A chain
  2. Tubulin beta-3 chain
IPR003008
Domain description: Tubulin/FtsZ, GTPase domain
Occurring in:
  1. Tubulin alpha-1A chain
  2. Tubulin beta-3 chain
IPR036525
Domain description: Tubulin/FtsZ, GTPase domain superfamily
Occurring in:
  1. Tubulin alpha-1A chain
  2. Tubulin beta-3 chain
IPR031378
Domain description: Small vasohibin-binding protein
Occurring in:
  1. Small vasohibin-binding protein
IPR028131
Domain description: Tubulinyl-Tyr carboxypeptidase
Occurring in:
  1. Tubulinyl-Tyr carboxypeptidase 1
IPR023123
Domain description: Tubulin, C-terminal
Occurring in:
  1. Tubulin alpha-1A chain
  2. Tubulin beta-3 chain
IPR037103
Domain description: Tubulin/FtsZ-like, C-terminal domain
Occurring in:
  1. Tubulin alpha-1A chain
  2. Tubulin beta-3 chain
IPR008280
Domain description: Tubulin/FtsZ, C-terminal
Occurring in:
  1. Tubulin alpha-1A chain
  2. Tubulin beta-3 chain
IPR017975
Domain description: Tubulin, conserved site
Occurring in:
  1. Tubulin alpha-1A chain
  2. Tubulin beta-3 chain
IPR013838
Domain description: Beta tubulin, autoregulation binding site
Occurring in:
  1. Tubulin beta-3 chain

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